PTC124 (Ataluren)

Catalog No. A10758

PTC124也称为Ataluren，是CFTR-G542X无意义等位基因抑制剂。

Product Citations

L Kadunc, .et al. Increased Gene Translation Stringency in Mammalian Cells by Nonsense Suppression at Multiple Permissive Sites With a Single Noncanonical Amino Acid, FEBS Lett, 2020, May 13 PMID: 32401336
Caspi M, .et al. A flow cytometry-based reporter assay identifies macrolide antibiotics as nonsense mutation read-through agents, J Mol Med (Berl), 2016, Apr;94(4):469-82 PMID: 26620677

Technical details

Catalog Num	A10758
M. Wt	284.2
Formula	C15H9FN2O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	775304-57-9
Synonyms	PTC-124, PTC 124
SMILES	C1=CC=C(C(=C1)C2=NC(=NO2)C3=CC(=CC=C3)C(=O)O)F

Biological Activity

PTC124也称为Ataluren，是CFTR-G542X无意义等位基因抑制剂。

Targets

CFTR (HEK293 cells)

Solubility *

In vitro (25°C)	DMSO	55 mg/mL (193.49 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.19 mL	175.93 mL	351.86 mL
0.5 mM	7.04 mL	35.19 mL	70.37 mL
1 mM	3.52 mL	17.59 mL	35.19 mL
5 mM	0.7 mL	3.52 mL	7.04 mL

*The above data is based on the productmolecular weight 284.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.