R406 besylate

Catalog No. A10769

R406 besylate是一种口服酪氨酸激酶抑制剂，IC50为41 nM。对Syk抑制作用强，但是不抑制Lyn，对Flt3的作用比对Syk低5倍。

Product Citations

Gabriella Leung, .et al. ARPC1B binds WASP to control actin polymerization and curtail tonic signaling in B cells, JCI insight, 2021, Dec 8;6(23):e149376 PMID: 34673575

Technical details

Catalog Num	A10769
M. Wt	628.6
Formula	C22H23FN6O5.C6H6O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	841290-81-1
Synonyms	R-406
SMILES	CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C.C1=CC=C(C=C1)S(=O)(=O)O

Biological Activity

R406 besylate是一种口服酪氨酸激酶抑制剂，IC50为41 nM。对Syk抑制作用强，但是不抑制Lyn，对Flt3的作用比对Syk低5倍。

Targets

Flt3 (Cell-free assay)	Syk (Cell-free assay)
N/A	41 nM

Solubility *

In vitro (25°C)	DMSO	92 mg/mL (146.34 mM)
	Water	Insoluble
	Ethanol
In vivo	5%dmso+95%cornoil	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.91 mL	79.54 mL	159.08 mL
0.5 mM	3.18 mL	15.91 mL	31.82 mL
1 mM	1.59 mL	7.95 mL	15.91 mL
5 mM	0.32 mL	1.59 mL	3.18 mL

*The above data is based on the productmolecular weight 628.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.