Roscovitine (Seliciclib)

Catalog No. A10806

Roscovitine (Seliciclib)是一种CDK抑制剂，可优先抑制多种酶靶标，包括CDK2，CDK7和CDK9。

Product Citations

Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
Vimal Pandey, .et al. Roscovitine effectively enhances antitumor activity of temozolomide in vitro and in vivo mediated by increased autophagy and Caspase-3 dependent apoptosis, Scientific Reports, 2019, 9, Article number: 5012 PMID: 30899038

Technical details

Catalog Num	A10806
M. Wt	354.5
Formula	C19H26N6O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	186692-46-6
Synonyms	CYC202, Seliciclib
SMILES	CC[C@H](CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C

Biological Activity

Roscovitine (Seliciclib)是一种CDK抑制剂，可优先抑制多种酶靶标，包括CDK2，CDK7和CDK9。

Targets

Target	Value
CDK5/p35	IC50: 0.16μM
Cdc2/CyclinB	IC50: 0.65μM
CDK2/CyclinA	IC50: 0.7μM
CDK2/CyclinE	IC50: 0.7μM
ERK2	IC50: 14μM
GST-ERK1	IC50: 30μM
ERK1	IC50: 34μM
CDK4/CyclinD1	IC50: >100μM
CDK6/CyclinD3	IC50: >100μM
PKCα	IC50: >100μM
PKCβ1	IC50: >100μM
PKCβ2	IC50: >100μM
PKCγ	IC50: 100μM
PKCε	IC50: >100μM
PKCη	IC50: >100μM
c-Src	IC50: 250μM
PKCδ	IC50: >1000μM
PKCζ	IC50: >1000μM
v-Abl	IC50: >1000μM

Solubility *

In vitro (25°C)	DMSO	69 mg/mL (194.67 mM)
	Water	Insoluble
	Ethanol	6 mg/mL (16.92 mM)
In vivo	1% DMSO+10% Tween 80+20% N-N-dimethylacetamide+69% PEG 400	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.21 mL	141.04 mL	282.09 mL
0.5 mM	5.64 mL	28.21 mL	56.42 mL
1 mM	2.82 mL	14.1 mL	28.21 mL
5 mM	0.56 mL	2.82 mL	5.64 mL

*The above data is based on the productmolecular weight 354.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.