S3I-201 (NSC 74859)

Catalog No. A10817

S3I-201(NSC 74859)是Stat3的新型抑制剂，可在体外抑制Stat3，Stat3复合物的形成以及Stat3-DNA结合活性（IC50 = 86±33 ?M）和Stat3依赖性转录活性。

Product Citations

Bae WJ, .et al. PTPRD-inactivation-induced CXCL8 promotes angiogenesis and metastasis in gastric cancer and is inhibited. J Exp Clin Cancer Res, 2019, 38:484 PMID: 31805999
Nishimura K, .et al. Effect of erythropoietin production induced by hypoxia on autophagy in HepG2 cells, Biochem Biophys Res Commun, 2018, Jan 1;495(1):1317-1321 PMID: 29191652
Ethan L. Morgan, .et al. STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle, PLoS Pathog, 2018, Apr; 14(4): e1006975 PMID: 29630659
Soleimani AH, .et al. Micellar nano-carriers for the delivery of STAT3 dimerization inhibitors to melanoma, Drug Deliv Transl Res, 2017, Aug;7(4):571-581 PMID: 28290050

Technical details

Catalog Num	A10817
M. Wt	365.4
Formula	C16H15NO7S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	501919-59-1
Synonyms	S3I201, NSC74859 , NSC-74859
SMILES	CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O

Biological Activity

S3I-201(NSC 74859)是Stat3的新型抑制剂，可在体外抑制Stat3，Stat3复合物的形成以及Stat3-DNA结合活性（IC50 = 86±33 ?M）和Stat3依赖性转录活性。

Targets

STAT3 (Cell-free assay)
86 μM

Solubility *

In vitro (25°C)	DMSO	66 mg/mL (180.64 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+corn oil	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.37 mL	136.84 mL	273.67 mL
0.5 mM	5.47 mL	27.37 mL	54.73 mL
1 mM	2.74 mL	13.68 mL	27.37 mL
5 mM	0.55 mL	2.74 mL	5.47 mL

*The above data is based on the productmolecular weight 365.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.