SB 431542

Catalog No. A10826

SB 431542是转化生长因子-β超家族I型激活素受体样激酶（ALK）受体ALK4，ALK5和ALK7的有效抑制剂。

Product Citations

Huong Pham, .et al. BMP11 Negatively Regulates Lipid Metabolism in C2C12 Muscle Cells, Biotechnol Bioprocess Eng, 2020, ID: 222137835
Tamara Chamberlin, .et al. Obesity Reduces Mammary Epithelial Cell TGFβ1 Activity Through Macrophage-Mediated Extracellular Matrix Remodeling, FASEB J, 2020, Jun;34(6):8611-8624 PMID: 32359100
Satoshi Endo, .et al. Flavonol glycosides of Rosa multiflora regulates intestinal barrier function through inhibiting claudin expression in differentiated Caco-2 cells, Nutr Res, 2019, 4 November

Technical details

Catalog Num	A10826
M. Wt	384.4
Formula	C22H16N4O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	301836-41-9
Synonyms	SB-431542, SB431542
SMILES	C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5

Biological Activity

SB 431542是转化生长因子-β超家族I型激活素受体样激酶（ALK）受体ALK4，ALK5和ALK7的有效抑制剂。

Targets

ALK4 (Cell-free assay)	ALK7 (Cell-free assay)	ALK5 (Cell-free assay)
N/A		94 nM

Solubility *

In vitro (25°C)	DMSO	75 mg/mL (195.11 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (7.8 mM)
In vivo	2% DMSO+30% PEG 300+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.01 mL	130.07 mL	260.15 mL
0.5 mM	5.2 mL	26.01 mL	52.03 mL
1 mM	2.6 mL	13.01 mL	26.01 mL
5 mM	0.52 mL	2.6 mL	5.2 mL

*The above data is based on the productmolecular weight 384.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.