Simvastatin

Catalog No. A10845

Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.

Technical details

Catalog Num	A10845
M. Wt	418.57
Formula	C25H38O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	79902-63-9
Synonyms	MK 733, MK-733, MK733
SMILES	CCC(C)(C)C(O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(O3)=O)[C@@]12[H])=O

Biological Activity

Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.

Solubility *

In vitro (25°C)	DMSO	71 mg/mL (169.62 mM)
	Water	Insoluble
	Ethanol	71 mg/mL (169.62 mM)
In vivo	2% DMSO+30% PEG 300+5% Tween80+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.89 mL	119.45 mL	238.91 mL
0.5 mM	4.78 mL	23.89 mL	47.78 mL
1 mM	2.39 mL	11.95 mL	23.89 mL
5 mM	0.48 mL	2.39 mL	4.78 mL

*The above data is based on the productmolecular weight 418.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

Simvastatin

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions