Sinomenine (Cucoline)

Catalog No. A10846

Sinomenine (Cucoline)在传统上用于草药，以治疗风湿病和关节炎。

Product Citations

Zheng Sun, .et al. Sinomenine inhibits the growth of melanoma by enhancement of autophagy via PI3K/AKT/mTOR inhibition, Drug Des Devel Ther, 2018, 12: 2413-2421 PMID: 30122899

Technical details

Catalog Num	A10846
M. Wt	329.4
Formula	C19H23NO4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	115-53-7
Synonyms	Cucoline, Kukoline, Coculine, Sabianine A
SMILES	CN1CC[C@@]23CC(=O)C(=C[C@@H]2[C@@H]1CC4=C3C(=C(C=C4)OC)O)OC

Biological Activity

Sinomenine (Cucoline)在传统上用于草药，以治疗风湿病和关节炎。

Targets

Solubility *

In vitro	DMSO	63 mg/mL (191.26 mM)
	Water	Warmed: 63 mg/mL (191.26 mM)
	Ethanol	7 mg/mL (21.25 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.36 mL	151.79 mL	303.58 mL
0.5 mM	6.07 mL	30.36 mL	60.72 mL
1 mM	3.04 mL	15.18 mL	30.36 mL
5 mM	0.61 mL	3.04 mL	6.07 mL

*The above data is based on the productmolecular weight 329.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.