Sitagliptin phosphate monohydrate

Catalog No. A10848

Sitagliptin phosphate monohydrate是二肽基肽酶-4（DPP-4）类的抗糖尿病（抗高血糖）药物。 DPP-4酶的抑制作用被认为会增加胰高血糖素样肽1（GLP-1），从而抑制胰高血糖素释放，刺激胰岛素释放并降低血糖。

Technical details

Catalog Num	A10848
M. Wt	523.3
Formula	C16H15F6N5O.H3PO4.H2O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	654671-77-9
Synonyms	Januvia, MK-0431
SMILES	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.O.OP(=O)(O)O

Biological Activity

Targets

DPP-4 (Cell-free assay)
19 nM

Solubility *

In vitro (25°C)	DMSO	85 mg/mL (162.42 mM)
	Water	35 mg/mL (66.88 mM)
	Ethanol	Insoluble
In vivo	Saline	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.11 mL	95.55 mL	191.09 mL
0.5 mM	3.82 mL	19.11 mL	38.22 mL
1 mM	1.91 mL	9.55 mL	19.11 mL
5 mM	0.38 mL	1.91 mL	3.82 mL

*The above data is based on the productmolecular weight 523.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.