SNS-314

Catalog No. A10851

SNS-314 Mesylate是Aurora A，Aurora B和Aurora C的有效和选择性抑制剂，IC50分别为9 nM，31 nM和3 nM。它对Trk A/B，Flt4，Fms，Axl，c-Raf和DDR2的效力较低。阶段1。

Technical details

Catalog Num	A10851
M. Wt	527.0
Formula	C18H15ClN6OS2.CH4O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1057249-41-8
Synonyms	SNS314
SMILES	CS(=O)(=O)O.C1=CC(=CC(=C1)Cl)NC(=O)NC2=NC=C(S2)CCNC3=NC=NC4=C3SC=C4

Biological Activity

SNS-314 Mesylate是Aurora A，Aurora B和Aurora C的有效和选择性抑制剂，IC50分别为9 nM，31 nM和3 nM。它对Trk A/B，Flt4，Fms，Axl，c-Raf和DDR2的效力较低。阶段1。

Targets

Aurora C	Aurora A	Aurora B
3 nM	9 nM	31 nM

Solubility *

In vitro	DMSO	Warmed: 80 mg/mL (151.79 mM)
	Water	Insoluble
	Ethanol	Warmed: 1 mg/mL (1.89 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.98 mL	94.88 mL	189.75 mL
0.5 mM	3.8 mL	18.98 mL	37.95 mL
1 mM	1.9 mL	9.49 mL	18.98 mL
5 mM	0.38 mL	1.9 mL	3.8 mL

*The above data is based on the productmolecular weight 527.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.