STF-62247

Catalog No. A10866

STF-62247是一种小分子激动剂，可诱导已经失去von Hippel-Lindau（VHL）肿瘤抑制活性（IC50 = 625 nM）的肾细胞癌（RCC）细胞致死，并自噬。

Technical details

Catalog Num	A10866
M. Wt	267.4
Formula	C15H13N3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	315702-99-9
Synonyms	STF62247
SMILES	CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3

Biological Activity

STF-62247是一种小分子激动剂，可诱导已经失去von Hippel-Lindau（VHL）肿瘤抑制活性（IC50 = 625 nM）的肾细胞癌（RCC）细胞致死，并自噬。

Targets

Solubility *

In vitro (25°C)	DMSO	47 mg/mL (175.8 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (11.22 mM)
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	6 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	37.4 mL	186.99 mL	373.97 mL
0.5 mM	7.48 mL	37.4 mL	74.79 mL
1 mM	3.74 mL	18.7 mL	37.4 mL
5 mM	0.75 mL	3.74 mL	7.48 mL

*The above data is based on the productmolecular weight 267.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.