Streptozotocin (Zanosar)

Catalog No. A10868

Streptozotocin (Streptozocin,Zanosar,STZ)用于医学研究中，用于产生1型糖尿病的动物模型，该模型直接抑制NCOAT酶在体外的O-GlcNAcase活性。

Product Citations

Andressa Braga, .et al. Free interstitial levels of metformin in the liver of healthy and diabetic Wistar rats, Braz J Pharm Sci, 2022, 58: e19674
Yuanyuan Du, .et al. Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates, Nat Med, 2022, Feb;28(2):272-282 PMID: 35115708
Karemah A. Alatawi, .et al. Coconut products alleviate hyperglycaemic, hyperlipidimic and nephropathy indices in streptozotocin-induced diabetic wistar rats, Saudi Journal of Biological Sciences, 2021, 25 June
D.H. Mhya, .et al. Evaluation of Anti-hyperglycemic Effect of Sub-fractions Derived from Ethanol-aqueous Fraction of Balanites aegyptiaca Leaves in Streptozotocin-induced Diabetic Rats, Asian J Exp Biol Sci, 2019, 12 (2): 164-172
Stanley I. R. Okoduwa, .et al. Validation of the antidiabetic effects of Vernonia amygdalina delile leaf fractions in fortified diet-fed streptozotocin-treated rat model of type-2 diabetes, J Diabetol, 2017, 8(3): 74-85
Stanley I. R. Okoduwa, .et al. Anti-Diabetic Potential of Ocimum gratissimum Leaf Fractions in Fortified Diet-Fed Streptozotocin Treated Rat Model of Type-2 Diabetes, Medicines (Basel), 2017, Dec; 4(4): 73 PMID: 29019956
Stanley I. R. Okoduwa, .et al. Appropriate Insulin Level in Selecting Fortified Diet-Fed, Streptozotocin-Treated Rat Model of Type 2 Diabetes for Anti-Diabetic Studies, PLoS One, 2017, 12(1): e0170971 PMID: 28129400
Stanley I. R. Okoduwa, .et al. Evaluation of extraction protocols for anti-diabetic phytochemical substances from medicinal plants, World J Diabetes, 2016, Dec 15; 7(20): 605-614 PMID: 28031778

Technical details

Catalog Num	A10868
M. Wt	265.2
Formula	C8H15N3O7
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	18883-66-4
Synonyms	Streptozocin, Zanosar, STZ
SMILES	CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO)O)O)N=O

Biological Activity

Streptozotocin (Streptozocin,Zanosar,STZ)用于医学研究中，用于产生1型糖尿病的动物模型，该模型直接抑制NCOAT酶在体外的O-GlcNAcase活性。

Targets

Solubility *

In vitro (25°C)	DMSO	51 mg/mL (192.29 mM)
	Water	51 mg/mL (192.29 mM)
	Ethanol	Insoluble
In vivo	Saline	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	37.71 mL	188.54 mL	377.07 mL
0.5 mM	7.54 mL	37.71 mL	75.41 mL
1 mM	3.77 mL	18.85 mL	37.71 mL
5 mM	0.75 mL	3.77 mL	7.54 mL

*The above data is based on the productmolecular weight 265.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.