Tigecycline

Catalog No. A10933

Tigecycline具有抑菌作用，是一种蛋白质合成抑制剂，可与细菌的30S核糖体亚基结合，从而在原核翻译过程中阻止氨酰tRNA进入核糖体的A位点。

Product Citations

Zewen Wen, .et al. In vitro activity and adaptation strategies of eravacycline in clinical Enterococcus faecium isolates from China, J Antibiot (Tokyo), 2022, Sep;75(9):498-508 PMID: 35896611
Xiaoming Liu, .et al. Comparison of antibacterial activities and resistance mechanisms of omadacycline and tigecycline against Enterococcus faecium, J Antibiot (Tokyo), 2022, Aug;75(8):463-471 PMID: 35760902
Sato T, .et al. Tigecycline Susceptibility of Klebsiella pneumoniae Complex and Escherichia coli Isolates from Companion Animals: The Prevalence of Tigecycline-Nonsusceptible K. pneumoniae Complex, Including Internationally Expanding Human Pathogenic Lineages, Microb Drug Resist, 2018, Jul/Aug;24(6):860-867 PMID: 29232167
Dinah B. Aziz, .et al. Teicoplanin ?C Tigecycline Combination Shows Synergy Against Mycobacterium abscessus, Front Microbiol, 2018, May 11 PMID: 29867841
Toyotaka Sato, .et al. Tigecycline Nonsusceptibility Occurs Exclusively in Fluoroquinolone-Resistant Escherichia coli Clinical Isolates, Including the Major Multidrug-Resistant Lineages O25b:H4-ST131-H30R and O1-ST648, Antimicrob Agents Chemother, 2017, Feb; 61(2): e01654-16 PMID: 27855067

Technical details

Catalog Num	A10933
M. Wt	585.7
Formula	C29H39N5O8
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	220620-09-7
Synonyms	Tygacil, GAR-936, WAY-GAR-936, TBG-MINO
SMILES	CC(C)(C)NCC(=O)NC1=C(C2=C(C[C@H]3C[C@H]4[C@@H](C(=O)C(=C([C@]4(C(=O)C3=C2O)O)O)C(=O)N)N(C)C)C(=C1)N(C)C)O

Biological Activity

Tigecycline具有抑菌作用，是一种蛋白质合成抑制剂，可与细菌的30S核糖体亚基结合，从而在原核翻译过程中阻止氨酰tRNA进入核糖体的A位点。

Solubility *

In vitro (25°C)	DMSO	86 mg/mL (146.85 mM)
	Water	86 mg/mL (146.85 mM)
	Ethanol	Insoluble
In vivo	Saline	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.07 mL	85.37 mL	170.74 mL
0.5 mM	3.41 mL	17.07 mL	34.15 mL
1 mM	1.71 mL	8.54 mL	17.07 mL
5 mM	0.34 mL	1.71 mL	3.41 mL

*The above data is based on the productmolecular weight 585.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.