Trichostatin-A (TSA)

Catalog No. A10947

Trichostatin-A (TSA)是抑制HDAC 1、3、4、6和10，IC50值约为20 nM。

Product Citations

Goudreault M, .et al. Afadin couples RAS GTPases to the polarity rheostat Scribble, Research Square, 2021, 22 Nov
Hiroyuki Imuta, .et al. Histone methylation and demethylation are implicated in the transient and sustained activation of the interleukin-1β gene in murine macrophages, Heart Vessels, 2020, Jul 16 PMID: 32676696
M??ndez-Blanco C, .et al. Stabilization of Hypoxia-Inducible Factors and BNIP3 Promoter Methylation Contribute to Acquired Sorafenib Resistance in Human Hepatocarcinoma Cells, Cancers (Basel), 2019, Dec 9;11(12). pii: E1984 PMID: 31835431

Technical details

Catalog Num	A10947
M. Wt	302.4
Formula	C17H22N2O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	58880-19-6
Synonyms	Trichostatin A
SMILES	C[C@H](/C=C(\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C

Biological Activity

Trichostatin-A (TSA)是抑制HDAC 1、3、4、6和10，IC50值约为20 nM。

Targets

HDAC (Cell-free assay)
~1.8 nM

Solubility *

In vitro (25°C)	DMSO	20 mg/mL (66.13 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	33.07 mL	165.34 mL	330.69 mL
0.5 mM	6.61 mL	33.07 mL	66.14 mL
1 mM	3.31 mL	16.53 mL	33.07 mL
5 mM	0.66 mL	3.31 mL	6.61 mL

*The above data is based on the productmolecular weight 302.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.