Vicriviroc Malate

Catalog No. A10971

Vicriviroc Malate是CCR5拮抗剂，也是HIV-1进入靶细胞的有效抑制剂，对HIV分离株的平均IC50 = 0.46 nM，IC50 = 1?10 nM（n = 52）。

Product Citations

Tomohiro Nabekura, .et al. Effects of Antiviral Drugs on Organic Anion Transport in Human Placental BeWo Cells, Antimicrob Agents Chemother, 2015, Dec; 59(12): 7666-7670 PMID: 26416870

Technical details

Catalog Num	A10971
M. Wt	667.7
Formula	C28H38F3N5O2.C4H6O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	541503-81-5
Synonyms
SMILES	C[C@H]1CN(CCN1[C@@H](COC)C2=CC=C(C=C2)C(F)(F)F)C3(CCN(CC3)C(=O)C4=C(N=CN=C4C)C)C.C(C(C(=O)O)O)C(=O)O

Biological Activity

Vicriviroc Malate是CCR5拮抗剂，也是HIV-1进入靶细胞的有效抑制剂，对HIV分离株的平均IC50 = 0.46 nM，IC50 = 1?10 nM（n = 52）。

Solubility *

In vitro	DMSO	121 mg/mL (181.21 mM)
	Water	34 mg/mL (50.92 mM)
	Ethanol	121 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	14.98 mL	74.88 mL	149.77 mL
0.5 mM	3 mL	14.98 mL	29.95 mL
1 mM	1.5 mL	7.49 mL	14.98 mL
5 mM	0.3 mL	1.5 mL	3 mL

*The above data is based on the productmolecular weight 667.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.