WP1130 (Degrasyn)

Catalog No. A10988

WP1130 (Degrasyn)是一种新型的选择性小分子去泛素酶抑制剂和Bcr/Abl破坏途径激活剂，可特异性和快速下调野生型和突变型Bcr/Abl蛋白，而不会影响慢性粒细胞性白血病（CML）中的bcr/abl基因表达细胞。

Technical details

Catalog Num	A10988
M. Wt	384.3
Formula	C19H18BrN3O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	856243-80-6
Synonyms	WP-1130, Degrasyn
SMILES	CCC[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N

Biological Activity

Targets

DUB (Cell-free assay)	Bcr-Abl (Cell-free assay)
N/A	1.8 μM

Solubility *

In vitro	DMSO	73 mg/mL (189.96 mM)
	Water	Insoluble
	Ethanol	17 mg/mL (44.24 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.02 mL	130.11 mL	260.21 mL
0.5 mM	5.2 mL	26.02 mL	52.04 mL
1 mM	2.6 mL	13.01 mL	26.02 mL
5 mM	0.52 mL	2.6 mL	5.2 mL

*The above data is based on the productmolecular weight 384.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.