TAK-875 (Fasiglifam)

Catalog No. A11018

TAK-875 (Fasiglifam)是一种有效的，选择性的GPR40激动剂。

Product Citations

Ying Liu, .et al. A synthetic free fatty acid-regulated transgene switch in mammalian cells and mice, Nucleic Acids Res, 2018, Oct 12; 46(18): 9864-9874 PMID: 30219861
Deborah A. Goldspink, .et al. Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells, Mol Metab, 2018, Jan; 7: 90-101 PMID: 29167062
Hodaka Yamada, .et al. Potentiation of Glucose-stimulated Insulin Secretion by the GPR40-PLC-TRPC Pathway in Pancreatic β-Cells, Sci Rep, 2016, 6: 25912 PMID: 27180622

Technical details

Catalog Num	A11018
M. Wt	524.6
Formula	C29H32O7S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1000413-72-8
Synonyms	TAK875
SMILES	CC1=C(C2=CC(COC3=CC=C([C@H](CC(O)=O)CO4)C4=C3)=CC=C2)C(C)=CC(OCCCS(C)(=O)=O)=C1

Biological Activity

TAK-875 (Fasiglifam)是一种有效的，选择性的GPR40激动剂。

Solubility *

In vitro (25°C)	DMSO	92 mg/mL (172.4 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% CMC+0.25% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.06 mL	95.31 mL	190.62 mL
0.5 mM	3.81 mL	19.06 mL	38.12 mL
1 mM	1.91 mL	9.53 mL	19.06 mL
5 mM	0.38 mL	1.91 mL	3.81 mL

*The above data is based on the productmolecular weight 524.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.