Geldanamycin

Catalog No. A11025

Geldanamycin与Hsp90的ATP位点（Kd = 1.2μM）结合并抑制其分子伴侣活性。

Product Citations

Michael Heider, .et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma, Mol Cell, 2021, Mar 18;81(6):1170-1186 PMID: 33571422

Technical details

Catalog Num	A11025
M. Wt	560.6
Formula	C29H40N2O9
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	30562-34-6
Synonyms
SMILES	C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C/C=C(/C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)\C)OC)OC(=O)N)\C)C)O)OC

Biological Activity

Geldanamycin与Hsp90的ATP位点（Kd = 1.2μM）结合并抑制其分子伴侣活性。

Targets

p185	HSP90 (N-terminal domain)	HSP90
70 nM	0.78 μM(Kd)	1.2 μM(Kd)

Solubility *

In vitro	DMSO	Warmed: 32 mg/mL (57.08 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.84 mL	89.19 mL	178.38 mL
0.5 mM	3.57 mL	17.84 mL	35.68 mL
1 mM	1.78 mL	8.92 mL	17.84 mL
5 mM	0.36 mL	1.78 mL	3.57 mL

*The above data is based on the productmolecular weight 560.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.