AV-412
Catalog No. A11028
AV-412是一种EGFR / HER2抑制剂，可与表皮生长因子受体（EGFR）和人表皮生长因子受体2（HER2）结合并抑制其生长，这可能会导致肿瘤生长和血管生成受到抑制。
- Le Zhang, .et al. High-throughput drug library screening identifies colchicine as a thyroid cancer inhibitor, Oncotarget, 2016, Apr 12; 7(15): 19948-19959 PMID: 26942566
| Catalog Num | A11028 |
|---|---|
| M. Wt | 851.4 |
| Formula | C27H28ClFN6O.2C7H8O3S |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 451493-31-5 |
| Synonyms | AV412, MP-412 |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CC(C)(C#CC1=CC2=C(C=C1NC(=O)C=C)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)N4CCN(CC4)C |
AV-412是一种EGFR / HER2抑制剂，可与表皮生长因子受体（EGFR）和人表皮生长因子受体2（HER2）结合并抑制其生长，这可能会导致肿瘤生长和血管生成受到抑制。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 11.75 mL | 58.73 mL | 117.45 mL |
| 0.5 mM | 2.35 mL | 11.75 mL | 23.49 mL |
| 1 mM | 1.17 mL | 5.87 mL | 11.75 mL |
| 5 mM | 0.23 mL | 1.17 mL | 2.35 mL |
*The above data is based on the productmolecular weight 851.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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