INCB018424 (Ruxolitinib)
Catalog No. A11041
INCB018424 (Ruxolitinib)是有效和选择性的Janus相关激酶JAK1/2抑制剂,对JAK1,JAK2和JAK3的IC50分别为2.7、4.5和332 nM。
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Catalog Num | A11041 |
---|---|
M. Wt | 306.4 |
Formula | C17H18N6 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 941678-49-5 |
Synonyms | Ruxolitinib, INCB18424 |
SMILES | C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3 |
INCB018424 (Ruxolitinib)是有效和选择性的Janus相关激酶JAK1/2抑制剂,对JAK1,JAK2和JAK3的IC50分别为2.7、4.5和332 nM。
In vitro (25°C) | DMSO | 59 mg/mL (192.57 mM) | |
Water | Insoluble | ||
Ethanol | 59 mg/mL (192.57 mM) | ||
In vivo | 2% DMSO+30% PEG 300+ddH2O | 4 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 32.64 mL | 163.19 mL | 326.37 mL |
0.5 mM | 6.53 mL | 32.64 mL | 65.27 mL |
1 mM | 3.26 mL | 16.32 mL | 32.64 mL |
5 mM | 0.65 mL | 3.26 mL | 6.53 mL |
*The above data is based on the productmolecular weight 306.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.