Crenolanib (CP-868596)

Catalog No. A11052

Crenolanib (CP-868596)是口服生物可用的PDGFR酪氨酸激酶的选择性小分子抑制剂，在皮摩尔浓度下抑制PDGFRA和PDGFRB。

Product Citations

N Naganna, .et al. Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice, EBioMedicine, 2019, Jan 24. pii: S2352-3964(19)30012-X PMID: 30686755

Technical details

Catalog Num	A11052
M. Wt	443.5
Formula	C26H29N5O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	670220-88-9
Synonyms	CP868596, CP 868596
SMILES	CC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4

Biological Activity

Crenolanib (CP-868596)是口服生物可用的PDGFR酪氨酸激酶的选择性小分子抑制剂，在皮摩尔浓度下抑制PDGFRA和PDGFRB。

Targets

PDGFRα (CHO cells)	PDGFRβ (CHO cells)	FLT3
2.1 nM(Kd)	3.2 nM(Kd)	0.74 nM (Kd)

Solubility *

In vitro (25°C)	DMSO	Warmed: 84 mg/mL (189.38 mM)
	Water	Insoluble
	Ethanol	7 mg/mL (15.78 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.55 mL	112.74 mL	225.48 mL
0.5 mM	4.51 mL	22.55 mL	45.1 mL
1 mM	2.25 mL	11.27 mL	22.55 mL
5 mM	0.45 mL	2.25 mL	4.51 mL

*The above data is based on the productmolecular weight 443.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.