BMS-536924

Catalog No. A11054

BMS-536924是有效的IGF-IR抑制剂，可导致IGF-IR介导的转化表型逆转。

Product Citations

Qiao Zhou, .et al. BMS-536924, an ATP-competitive IGF-1R/IR inhibitor, decreases viability and migration of temozolomide-resistant glioma cells in vitro and suppresses tumor growth in vivo, Onco Targets Ther., 2015, 8: 689-697 PMID: 25897243

Technical details

Catalog Num	A11054
M. Wt	480.0
Formula	C25H26ClN5O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	468740-43-4
Synonyms	BMS536924
SMILES	CC1=CC(=CC2=C1N/C(=C/3\C(=CC=NC3=O)NC[C@H](C4=CC(=CC=C4)Cl)O)/N2)N5CCOCC5

Biological Activity

BMS-536924是有效的IGF-IR抑制剂，可导致IGF-IR介导的转化表型逆转。

Targets

Target	Value
Insulin Receptor	IC50: 73nM
IGF-1R	IC50: 100nM
FAK	IC50: 150nM
MEK	IC50: 182nM
LCK	IC50: 341nM
CDK2/CyclinE	IC50: >1μM
VEGFR2	IC50: 1.4μM
EGF	IC50: 1.6μM
Met	IC50: 4.87μM
MAPK2	IC50: ~5μM
MAPK1	IC50: >5μM
Akt1	IC50: >5μM
PDGFR	IC50: >5μM
HER2	IC50: 17.1μM

Solubility *

In vitro (25°C)	DMSO	92 mg/mL (191.68 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.83 mL	104.17 mL	208.33 mL
0.5 mM	4.17 mL	20.83 mL	41.67 mL
1 mM	2.08 mL	10.42 mL	20.83 mL
5 mM	0.42 mL	2.08 mL	4.17 mL

*The above data is based on the productmolecular weight 480.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.