AMG 900

Catalog No. A11066

AMG 900是一种新型有效且高度选择性的泛Aurora激酶抑制剂，在紫杉烷抗性肿瘤细胞系中具有活性。

Product Citations

Tomoya Takeda, .et al. AT9283 exhibits antiproliferative effect on tyrosine kinase inhibitor-sensitive and -resistant chronic myeloid leukemia cells by inhibition of Aurora A and Aurora B, Oncol Rep, 2020, August 18

Technical details

Catalog Num	A11066
M. Wt	503.6
Formula	C28H21N7OS
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	945595-80-2
Synonyms	AMG-900, AMG900
SMILES	CC1=CSC(=C1)C2=NN=C(C3=CC=CC=C32)NC4=CC=C(C=C4)OC5=C(C=CC=N5)C6=NC(=NC=C6)N

Biological Activity

AMG 900是一种新型有效且高度选择性的泛Aurora激酶抑制剂，在紫杉烷抗性肿瘤细胞系中具有活性。

Targets

Target	Value
AuroraC	IC50: 1nM
AuroraB	IC50: 4nM
AuroraA	IC50: 5nM
p38α	IC50: 53nM
TYK2	IC50: 220nM
JNK2	IC50: 520nM
Met	IC50: 550nM
Tie-2	IC50: 650nM

Solubility *

In vitro (25°C)	DMSO	90 mg/mL (178.71 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	19 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.86 mL	99.29 mL	198.57 mL
0.5 mM	3.97 mL	19.86 mL	39.71 mL
1 mM	1.99 mL	9.93 mL	19.86 mL
5 mM	0.4 mL	1.99 mL	3.97 mL

*The above data is based on the productmolecular weight 503.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.