PKI-587 ( Gedatolisib )

Catalog No. A11079

PKI-587 (Gedatolisib)是一种高效的PI3K/mTOR激酶抑制剂，可抑制PI3K-α，β，γ，δ亚型和mTOR，IC50分别为0.4、6.0、5.4、6.0和1.6 nM。

Technical details

Catalog Num	A11079
M. Wt	615.7
Formula	C32H41N9O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1197160-78-3
Synonyms	PKI587, Gedatolisib
SMILES	CN(C)C1CCN(CC1)C(=O)C2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)C4=NC(=NC(=N4)N5CCOCC5)N6CCOCC6

Biological Activity

PKI-587 (Gedatolisib)是一种高效的PI3K/mTOR激酶抑制剂，可抑制PI3K-α，β，γ，δ亚型和mTOR，IC50分别为0.4、6.0、5.4、6.0和1.6 nM。

Targets

PI3Kα (Cell-free assay)	mTOR (Cell-free assay)	PI3Kγ (Cell-free assay)
0.4 nM	1.6 nM	5.4 nM

Solubility *

In vitro	DMSO	2 mg/mL (3.24 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.24 mL	81.21 mL	162.42 mL
0.5 mM	3.25 mL	16.24 mL	32.48 mL
1 mM	1.62 mL	8.12 mL	16.24 mL
5 mM	0.32 mL	1.62 mL	3.25 mL

*The above data is based on the productmolecular weight 615.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.