GW788388

Catalog No. A11083

GW788388是有效的，口服活性的，选择性的转化生长因子β受体I（TGF-βR1）（激活素受体样激酶5，ALK5）抑制剂,无细胞试验中IC50为18 nM，也抑制TGF-βII型受体和activin II型受体活性，但不抑制BMP II型受体。

Technical details

Catalog Num	A11083
M. Wt	425.5
Formula	C25H23N5O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	452342-67-5
Synonyms	GW-788388
SMILES	C1COCCC1NC(=O)C2=CC=C(C=C2)C3=NC=CC(=C3)C4=C(NN=C4)C5=CC=CC=N5

Biological Activity

Targets

ALK5 (Cell-free assay)
18 nM

Solubility *

In vitro (25°C)	DMSO	15 mg/mL (35.25 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.5 mL	117.51 mL	235.02 mL
0.5 mM	4.7 mL	23.5 mL	47 mL
1 mM	2.35 mL	11.75 mL	23.5 mL
5 mM	0.47 mL	2.35 mL	4.7 mL

*The above data is based on the productmolecular weight 425.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.