ARQ 197 (Tivantinib)

Catalog No. A11087

ARQ-197是c-Met受体酪氨酸激酶的选择性抑制剂, 在无细胞试验中Ki为0.355 μM，对Ron几乎没有作用活性，对EGFR， InsR， PDGFRα和FGFR1/4没有抑制作用。

Product Citations

Wang L, .et al. Bispecific Aptamer Induced Artificial Protein-Pairing: A Strategy for Selective Inhibition of Receptor Function, J Am Chem Soc, 2019, Aug 14;141(32):12673-12681 PMID: 31381313
Koide H, .et al. Substrate-dependent effects of molecular-targeted anticancer agents on activity of organic anion transporting polypeptide 1B1, Xenobiotica, 2018, Oct;48(10):1059-1071 PMID: 29034773

Technical details

Catalog Num	A11087
M. Wt	369.4
Formula	C23H19N3O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1000873-98-2, 905854-02-6
Synonyms	ARQ197
SMILES	C1CC2=CC=CC3=C2N(C1)C=C3[C@H]4[C@@H](C(=O)NC4=O)C5=CNC6=CC=CC=C65

Biological Activity

ARQ-197是c-Met受体酪氨酸激酶的选择性抑制剂, 在无细胞试验中Ki为0.355 μM，对Ron几乎没有作用活性，对EGFR， InsR， PDGFRα和FGFR1/4没有抑制作用。

Solubility *

In vitro	DMSO	69 mg/mL (186.77 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.07 mL	135.35 mL	270.71 mL
0.5 mM	5.41 mL	27.07 mL	54.14 mL
1 mM	2.71 mL	13.54 mL	27.07 mL
5 mM	0.54 mL	2.71 mL	5.41 mL

*The above data is based on the productmolecular weight 369.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.