AS-252424

Catalog No. A11099

AS-252424是有效的PI3K抑制剂，对γ亚型具有选择性。它抑制人重组PI3Kγ，α，β和δ，IC50值分别为30、940、20,000和20,000 nM。

Technical details

Catalog Num	A11099
M. Wt	305.3
Formula	C14H8FNO4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	900515-16-4
Synonyms	AS252424
SMILES	C1=CC(=C(C=C1F)O)C2=CC=C(O2)/C=C\3/C(=O)NC(=O)S3

Biological Activity

AS-252424是有效的PI3K抑制剂，对γ亚型具有选择性。它抑制人重组PI3Kγ，α，β和δ，IC50值分别为30、940、20,000和20,000 nM。

Targets

Casein Kinase 2 (Cell-free assay)	PI3Kγ (Cell-free assay)	PI3Kα (Cell-free assay)
20 nM	33 nM	935 nM

Solubility *

In vitro (25°C)	DMSO	57 mg/mL (186.71 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+50% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.75 mL	163.77 mL	327.55 mL
0.5 mM	6.55 mL	32.75 mL	65.51 mL
1 mM	3.28 mL	16.38 mL	32.75 mL
5 mM	0.66 mL	3.28 mL	6.55 mL

*The above data is based on the productmolecular weight 305.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.