Aliskiren hemifumarate

Catalog No. A11123

Aliskiren hemifumarate是阿利吉仑的半富马酸盐形式，是批准用于治疗原发性高血压的直接肾素抑制剂，IC50为1.5 nM。

Technical details

Catalog Num	A11123
M. Wt	609.8
Formula	C30H53N3O6.1/2C4H4O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	173334-58-2
Synonyms
SMILES	CC(C)[C@@H](CC1=CC(=C(C=C1)OC)OCCCOC)C[C@@H]([C@H](C[C@@H](C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.CC(C)[C@@H](CC1=CC(=C(C=C1)OC)OCCCOC)C[C@@H]([C@H](C[C@@H](C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.C(=C/C(=O)O)\C(=O)O

Biological Activity

Aliskiren hemifumarate是阿利吉仑的半富马酸盐形式，是批准用于治疗原发性高血压的直接肾素抑制剂，IC50为1.5 nM。

Targets

Renin
1.5 nM

Solubility *

In vitro	DMSO	89 mg/mL (145.94 mM)
	Water	89 mg/mL (145.94 mM)
	Ethanol	89 mg/mL (145.94 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.4 mL	81.99 mL	163.99 mL
0.5 mM	3.28 mL	16.4 mL	32.8 mL
1 mM	1.64 mL	8.2 mL	16.4 mL
5 mM	0.33 mL	1.64 mL	3.28 mL

*The above data is based on the productmolecular weight 609.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.