LY2109761

Catalog No. A11133

LY2109761是一种新型的I型和II型转化生长因子β受体双重抑制剂，对Smad2的磷酸化产生负面影响，作为抑制胰腺癌转移的治疗方法。

Product Citations

Uto T, .et al. Critical role of plasmacytoid dendritic cells in induction of oral tolerance, J Allergy Clin Immunol, 2018, Jun;141(6):2156-2167.e9 PMID: 29477579
Jared M. Fischer, .et al. Single cell lineage tracing reveals a role for TgfβR2 in intestinal stem cell dynamics and differentiation, Proc Natl Acad Sci U S A, 2016, Oct 25; 113(43): 12192-12197 PMID: 27791005

Technical details

Catalog Num	A11133
M. Wt	441.5
Formula	C26H27N5O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	700874-71-1
Synonyms	LY-2109761
SMILES	C1CC2=C(C(=NN2C1)C3=CC=CC=N3)C4=C5C=CC(=CC5=NC=C4)OCCN6CCOCC6

Biological Activity

LY2109761是一种新型的I型和II型转化生长因子β受体双重抑制剂，对Smad2的磷酸化产生负面影响，作为抑制胰腺癌转移的治疗方法。

Solubility *

In vitro (25°C)	DMSO	2 mg/mL (4.52 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% CMC+0.25% Tween 80 (suspensions)	15 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.65 mL	113.25 mL	226.5 mL
0.5 mM	4.53 mL	22.65 mL	45.3 mL
1 mM	2.27 mL	11.33 mL	22.65 mL
5 mM	0.45 mL	2.27 mL	4.53 mL

*The above data is based on the productmolecular weight 441.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.