CUDC-907 (Fimepinostat)

Catalog No. A11153

CUDC-907 (Fimepinostat)是针对PI3K和HDAC的单一小分子抑制剂，作用于PI3Kα和HDAC1/2/3/10，IC50分别为19 nM和1.7 nM/5 nM/1.8 nM/2.8 nM。

Product Citations

Chie Ishikawa, .et al. The role of CUDC-907, a dual phosphoinositide-3 kinase and histone deacetylase inhibitor, in inhibiting proliferation of adult T-cell leukemia, Eur J Haematol, 2020, Eur J Haematol PMID: 32780889

Technical details

Catalog Num	A11153
M. Wt	508.6
Formula	C23H24N8O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1339928-25-4
Synonyms	CUDC907
SMILES	CN(CC1=CC2=C(S1)C(=NC(=N2)C3=CN=C(C=C3)OC)N4CCOCC4)C5=NC=C(C=N5)C(=O)NO

Biological Activity

CUDC-907 (Fimepinostat)是针对PI3K和HDAC的单一小分子抑制剂，作用于PI3Kα和HDAC1/2/3/10，IC50分别为19 nM和1.7 nM/5 nM/1.8 nM/2.8 nM。

Targets

Target	Value
HDAC1	IC50: 1.7nM
HDAC3	IC50: 1.8nM
HDAC10	IC50: 2.8nM
HDAC2	IC50: 5.0nM
HDAC11	IC50: 5.4nM
PI3Kα	IC50: 19nM
HDAC6	IC50: 27nM
PI3Kδ	IC50: 39nM
PI3Kβ	IC50: 54nM
HDAC8	IC50: 191nM
PI3Kγ	IC50: 311nM
HDAC4	IC50: 409nM
HDAC7	IC50: 426nM
HDAC9	IC50: 554nM
HDAC5	IC50: 674nM

Solubility *

In vitro	DMSO	87 mg/mL (171.07 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.66 mL	98.31 mL	196.62 mL
0.5 mM	3.93 mL	19.66 mL	39.32 mL
1 mM	1.97 mL	9.83 mL	19.66 mL
5 mM	0.39 mL	1.97 mL	3.93 mL

*The above data is based on the productmolecular weight 508.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.