SB-505124

Catalog No. A11157

SB-505124是转化生长因子-βI型受体（ALK5），ALK4和ALK7的选择性抑制剂（ALK5和ALK4的IC50值分别为47和129 nM）。

Technical details

Catalog Num	A11157
M. Wt	335.4
Formula	C20H21N3O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	694433-59-5
Synonyms	SB505124
SMILES	CC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=C(C=C3)OCO4

Biological Activity

SB-505124是转化生长因子-βI型受体（ALK5），ALK4和ALK7的选择性抑制剂（ALK5和ALK4的IC50值分别为47和129 nM）。

Targets

ALK5 (Cell-free assay)	ALK4 (Cell-free assay)
47 nM	129 nM

Solubility *

In vitro (25°C)	DMSO	65 mg/mL (193.8 mM)
	Water	Insoluble
	Ethanol	65 mg/mL (193.8 mM)
In vivo	5%DMSO+40%PEG300+5%Tween80+50%ddH2O	7.1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.82 mL	149.08 mL	298.15 mL
0.5 mM	5.96 mL	29.82 mL	59.63 mL
1 mM	2.98 mL	14.91 mL	29.82 mL
5 mM	0.6 mL	2.98 mL	5.96 mL

*The above data is based on the productmolecular weight 335.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.