Wortmannin

Catalog No. A11161

Wortmannin是一种有效的，选择性的，可透过细胞的且不可逆的磷脂酰肌醇3-激酶（PI 3-激酶）（IC50 = 2-4 nM）抑制剂，它也有效抑制polo-like激酶1（PLK1）（IC50 = 5.8 nM）。

Product Citations

Dongdong Fang, etc. Epithelial-Mesenchymal Transition of Ovarian Cancer Cells Is Sustained by Rac1 through Simultaneous Activation of MEK1/2 and Src Signaling Pathways. Oncogene. 2017 Mar; 36(11): 1546–1558.

Technical details

Catalog Num	A11161
M. Wt	428.43
Formula	C23H24O8
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	19545-26-7
Synonyms	SL-2052
SMILES	CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)C5=COC(=C54)C3=O)COC)C)C

Biological Activity

Targets

PI3K (Cell-free assay)	DNA-PK [12](Cell-free assay)	ATM [12](Cell-free assay)	MLCK (Cell-free assay)	ATR [12](Cell-free assay)
3 nM	16 nM	150 nM	170 nM	1.8 μM

Solubility *

In vitro (25°C)	DMSO	73 mg/mL (170.38 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+40% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.34 mL	116.71 mL	233.41 mL
0.5 mM	4.67 mL	23.34 mL	46.68 mL
1 mM	2.33 mL	11.67 mL	23.34 mL
5 mM	0.47 mL	2.33 mL	4.67 mL

*The above data is based on the productmolecular weight 428.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.