GSK1070916

Catalog No. A11168

GSK1070916是一种有效的Aurora B/C激酶抑制剂（IC50为3.5 nM/6.5 nM），在组织培养细胞和人肿瘤异种移植模型中具有广泛的抗肿瘤活性。

Technical details

Catalog Num	A11168
M. Wt	507.63
Formula	C30H33N7O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	942918-07-2
Synonyms	GSK-1070916
SMILES	CCN1C=C(C(=N1)C2=CC=C(C=C2)NC(=O)N(C)C)C3=C4C=C(NC4=NC=C3)C5=CC(=CC=C5)CN(C)C

Biological Activity

GSK1070916是一种有效的Aurora B/C激酶抑制剂（IC50为3.5 nM/6.5 nM），在组织培养细胞和人肿瘤异种移植模型中具有广泛的抗肿瘤活性。

Targets

Target	Value
AuroraB-INCENP	IC50: 3.5nM
AuroraC-INCENP	IC50: 6.5nM
FLT1	IC50: 42nM
Tie-2	IC50: 59nM
SIK	IC50: 70nM
FLT4	IC50: 74nM
FGFR1	IC50: 76nM
AuroraA-TPX2	IC50: 1.1μM

Solubility *

In vitro (25°C)	DMSO	91 mg/mL (179.26 mM)
	Water	Insoluble
	Ethanol	8 mg/mL (15.75 mM)
In vivo	2% Cremophor EL, 2% N,N-dimethylacetamide, pH 5.0	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.7 mL	98.5 mL	196.99 mL
0.5 mM	3.94 mL	19.7 mL	39.4 mL
1 mM	1.97 mL	9.85 mL	19.7 mL
5 mM	0.39 mL	1.97 mL	3.94 mL

*The above data is based on the productmolecular weight 507.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.