YO-01027

Catalog No. A11174

YO-01027是一种二肽γ-secretase抑制剂，作用于APPL和Notch分裂，无细胞试验中IC50分别为2.6 nM和2.9 nM，一种抗阿尔茨海默氏病药物。

Technical details

Catalog Num	A11174
M. Wt	463.48
Formula	C26H23F2N3O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	209984-56-5
Synonyms	YO01027, Dibenzazepine, Deshydroxy LY 411575
SMILES	C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F

Biological Activity

YO-01027是一种二肽γ-secretase抑制剂，作用于APPL和Notch分裂，无细胞试验中IC50分别为2.6 nM和2.9 nM，一种抗阿尔茨海默氏病药物。

Targets

γ secretase(APPL) (Cell-free assay)	γ secretase(Notch) (Cell-free assay)
2.6 nM	2.9 nM

Solubility *

In vitro (25°C)	DMSO	87 mg/mL (187.7 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% hydroxyethyl cellulose	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.58 mL	107.88 mL	215.76 mL
0.5 mM	4.32 mL	21.58 mL	43.15 mL
1 mM	2.16 mL	10.79 mL	21.58 mL
5 mM	0.43 mL	2.16 mL	4.32 mL

*The above data is based on the productmolecular weight 463.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.