BRL-15572 dihydrochloride

Catalog No. A11178

BRL-15572是一种选择性的h5-HT1D拮抗剂，相对于h5-HT1B表现出60倍的选择性，对一系列其他受体类型的亲和力很小或没有亲和力。

Technical details

Catalog Num	A11178
M. Wt	479.87
Formula	C25H29Cl3N2O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	193611-72-2
Synonyms	BRL15572
SMILES	C1CN(CCN1CC(C(C2=CC=CC=C2)C3=CC=CC=C3)O)C4=CC(=CC=C4)Cl.Cl.Cl

Biological Activity

BRL-15572是一种选择性的h5-HT1D拮抗剂，相对于h5-HT1B表现出60倍的选择性，对一系列其他受体类型的亲和力很小或没有亲和力。

Targets

Target	Value
5-HT1D	pki: 7.9
5-HT1A	pki: 7.7
5-HT2B	pki: 7.4
5-HT2A	pki: 6.6
5-HT7	pki: 6.3
5-HT2C	pki: 6.2
5-HT1B	pki: 6.1
5-HT1F	pki: 6
5-HT6	pki: 5.9
5-HT1E	pki: 5.2

Solubility *

In vitro (25°C)	DMSO	89 mg/mL (185.46 mM)
	Water	Insoluble
	Ethanol	37 mg/mL (77.1 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	19 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.84 mL	104.19 mL	208.39 mL
0.5 mM	4.17 mL	20.84 mL	41.68 mL
1 mM	2.08 mL	10.42 mL	20.84 mL
5 mM	0.42 mL	2.08 mL	4.17 mL

*The above data is based on the productmolecular weight 479.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.