ADX-47273

Catalog No. A11181

ADX-47273是一种有效的，特异性的mGlu5正变构调节剂(PAM)EC50为0.17 μM，对其他亚型没有作用活性。

Technical details

Catalog Num	A11181
M. Wt	369.36
Formula	C20H17F2N3O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	851881-60-2
Synonyms	ADX47273
SMILES	C1C[C@@H](CN(C1)C(=O)C2=CC=C(C=C2)F)C3=NC(=NO3)C4=CC=C(C=C4)F

Biological Activity

ADX-47273是一种有效的，特异性的mGlu5正变构调节剂(PAM)EC50为0.17 μM，对其他亚型没有作用活性。

Targets

mGlu5
0.17 μM(EC50)

Solubility *

In vitro (25°C)	DMSO	73 mg/mL (197.63 mM)
	Water	Insoluble
	Ethanol	29 mg/mL (78.51 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.07 mL	135.37 mL	270.74 mL
0.5 mM	5.41 mL	27.07 mL	54.15 mL
1 mM	2.71 mL	13.54 mL	27.07 mL
5 mM	0.54 mL	2.71 mL	5.41 mL

*The above data is based on the productmolecular weight 369.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.