Clinofibrate

Catalog No. A11184

Clinofibrate是一种脂质清除剂，似乎可以改变脂质代谢，减少类固醇诱导的骨细胞内脂质堆积。它还可以有效降低血浆纤维蛋白原水平。抑制hydroxymethylglutaryl coenzyme A reductase (HMGCR)（羟甲基戊二酰辅酶A还原酶），IC50为0.47 mM。

Technical details

Catalog Num	A11184
M. Wt	468.58
Formula	C28H36O6
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	30299-08-2
Synonyms	Lipoclin
SMILES	CCC(C(O)=O)(C)OC1=CC=C(C=C1)C2(CCCCC2)C3=CC=C(C=C3)OC(CC)(C)C(O)=O

Biological Activity

Targets

HMGCR
0.47 mM

Solubility *

In vitro	DMSO	90 mg/mL (192.06 mM)
	Water	Insoluble
	Ethanol	90 mg/mL (192.06 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.34 mL	106.71 mL	213.41 mL
0.5 mM	4.27 mL	21.34 mL	42.68 mL
1 mM	2.13 mL	10.67 mL	21.34 mL
5 mM	0.43 mL	2.13 mL	4.27 mL

*The above data is based on the productmolecular weight 468.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.