TWS119

Catalog No. A11223

TWS119是4,6双取代的吡咯并嘧啶，可有效抑制GSK3β，IC50值为30 nM。

Technical details

Catalog Num	A11223
M. Wt	318.3
Formula	C18H14N4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	601514-19-6
Synonyms	TWS-119
SMILES	C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O

Biological Activity

TWS119是4,6双取代的吡咯并嘧啶，可有效抑制GSK3β，IC50值为30 nM。

Targets

GSK-3β (Cell-free assay)
30 nM

Solubility *

In vitro (25°C)	DMSO	58 mg/mL (182.19 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.42 mL	157.08 mL	314.17 mL
0.5 mM	6.28 mL	31.42 mL	62.83 mL
1 mM	3.14 mL	15.71 mL	31.42 mL
5 mM	0.63 mL	3.14 mL	6.28 mL

*The above data is based on the productmolecular weight 318.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.