Pluripotin (SC-1)

Catalog No. A11225

Pluripotin (SC-1)的活性是通过联合抑制RasGAP和ERK1介导的，其Kd值分别为98和212 nM。

Product Citations

Mohammad Azhar, .et al. Rational polypharmacological targeting of FLT3, JAK2, ABL, and ERK1 suppresses the adaptive resistance to FLT3 inhibitors in AML, Blood Adv, 2022, Aug 31 PMID: 36044389

Technical details

Catalog Num	A11225
M. Wt	550.5
Formula	C27H25F3N8O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	839707-37-8
Synonyms	SC-1
SMILES	Cc1nn(C)c(Nc2ncc3CN(c4cc(ccc4C)NC(=O)c4cccc(c4)C(F)(F)F)C(=O)N(C)c3n2)c1

Biological Activity

Pluripotin (SC-1)的活性是通过联合抑制RasGAP和ERK1介导的，其Kd值分别为98和212 nM。

Targets

ERK1	RasGAP
98 nM(Kd)	212 nM(Kd)

Solubility *

In vitro	DMSO	96 mg/mL (174.37 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.17 mL	90.83 mL	181.65 mL
0.5 mM	3.63 mL	18.17 mL	36.33 mL
1 mM	1.82 mL	9.08 mL	18.17 mL
5 mM	0.36 mL	1.82 mL	3.63 mL

*The above data is based on the productmolecular weight 550.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.