PF 429242

Catalog No. A11230

PF 429242是固醇调节元件结合蛋白（SREBP）位点1蛋白酶的可逆竞争性抑制剂。

Product Citations

Kai Xue, .et al. Advanced Oxidation Protein Product Promotes Oxidative Accentuation in Renal Epithelial Cells via the Soluble (Pro)renin Receptor-Mediated Intrarenal Renin-Angiotensin System and Nox4-H2O2 Signaling, Oxid Med Cell Longev, 2021, Nov 26;2021:5710440 PMID: 34873430
Tong-bing Wang, .et al. SREBP1 site 1 protease inhibitor PF-429242 suppresses renal cell carcinoma cell growth, Cell Death Dis, 2021, Aug; 12(8): 717 PMID: 34285190
Shiying Xie, .et al. Soluble (pro)renin receptor promotes fibrotic response in renal proximal tubule epithelial cells in vitro via Akt/β-catenin/Snail signaling pathway, Am J Physiol Renal Physiol, 2020, Aug 31 PMID: 32865015
Yang PM, .et al. p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma, Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
Hui Fang, .et al. (Pro)renin receptor mediates albumin-induced cellular responses: role of site-1 protease-derived soluble (pro)renin receptor in renal epithelial cells, Am J Physiol Cell Physiol, 2017, Dec 1; 313(6): C632-C643 PMID: 28903918
Tsutomu Nakagawa, .et al. Site-1 protease is required for the generation of soluble (pro)renin receptor, J Biochem, 2016, Apr 1;161(4):369-379 PMID: 28013223
Shimada S, .et al. Therapeutic effect of post-exposure treatment with antiserum on severe fever with thrombocytopenia syndrome (SFTS) in a mouse model of SFTS virus infection, Virology, 2015, Aug;482:19-27 PMID: 25817401
Jan H. Reiling, .et al. A Luman/CREB3-ADP-ribosylation factor 4 (ARF4) signaling pathway mediates the response to Golgi stress and susceptibility to pathogens, Nat Cell Biol., 2013, 15(12): 1473-1485 PMID: 24185178

Technical details

Catalog Num	A11230
M. Wt	409.56
Formula	C25H35N3O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	947303-87-9
Synonyms	PF-429242, PF429242
SMILES	CCN(CC)CC1=CC=C(C=C1)C(=O)N(CCC2=CC=CC=C2OC)[C@@H]3CCNC3

Biological Activity

PF 429242是固醇调节元件结合蛋白（SREBP）位点1蛋白酶的可逆竞争性抑制剂。

Solubility *

In vitro	DMSO	77 mg/mL (188 mM)
	Water
	Ethanol
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.42 mL	122.08 mL	244.16 mL
0.5 mM	4.88 mL	24.42 mL	48.83 mL
1 mM	2.44 mL	12.21 mL	24.42 mL
5 mM	0.49 mL	2.44 mL	4.88 mL

*The above data is based on the productmolecular weight 409.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.