BMS-911543

Catalog No. A11241

BMS-911543是一种有效的、选择性JAK2小分子抑制剂。

Technical details

Catalog Num	A11241
M. Wt	432.52
Formula	C23H28N8O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1271022-90-2
Synonyms	BMS911543, BMS 911543
SMILES	CCN1C(=CC2=C3C(=C(N=C21)NC4=NN(C(=C4)C)C)N=CN3C)C(=O)N(C5CC5)C6CC6

Biological Activity

BMS-911543是一种有效的、选择性JAK2小分子抑制剂。

Targets

JAK2	SET-2	TYK2	JAK3	JAK1
1.1 nM	60 nM	66 nM	75 nM	360 nM

Solubility *

In vitro	DMSO	36 mg/mL (83.23 mM)
	Water	Insoluble
	Ethanol	22 mg/mL (50.86 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.12 mL	115.6 mL	231.2 mL
0.5 mM	4.62 mL	23.12 mL	46.24 mL
1 mM	2.31 mL	11.56 mL	23.12 mL
5 mM	0.46 mL	2.31 mL	4.62 mL

*The above data is based on the productmolecular weight 432.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.