LY 2874455

Catalog No. A11244

LY2874455是一种新型有效的FGFR / VEGFR抑制剂。

Technical details

Catalog Num	A11244
M. Wt	444.31
Formula	C21H19Cl2N5O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1254473-64-7
Synonyms	LY-2874455, LY2874455
SMILES	C[C@H](C1=C(C=NC=C1Cl)Cl)OC2=CC3=C(C=C2)NN=C3/C=C/C4=CN(N=C4)CCO

Biological Activity

LY2874455是一种新型有效的FGFR / VEGFR抑制剂。

Targets

FGFR2	FGFR1	FGFR4	FGFR3	VEGFR2
2.6 nM	2.8 nM	6 nM	6.4 nM	7 nM

Solubility *

In vitro (25°C)	DMSO	86 mg/mL (193.55 mM)
	Water	Insoluble
	Ethanol	Warmed: 56 mg/mL (126.03 mM)
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.51 mL	112.53 mL	225.07 mL
0.5 mM	4.5 mL	22.51 mL	45.01 mL
1 mM	2.25 mL	11.25 mL	22.51 mL
5 mM	0.45 mL	2.25 mL	4.5 mL

*The above data is based on the productmolecular weight 444.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.