Cobicistat (GS-9350)

Catalog No. A11277

Cobicistat (GS-9350)是有效，选择性的细胞色素酶P450 3A (CYP3A)抑制剂，包括重要的cyp3a4亚型。它还抑制肠道转运蛋白，增加几种hiv药物的整体吸收，包括atazanavir、darunavir和tenofovir alafenamide延胡索酸盐。

Technical details

Catalog Num	A11277
M. Wt	766.0
Formula	C40H53N7O5S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1004316-88-4
Synonyms	GS9350
SMILES	CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5

Biological Activity

Targets

CYP3A
30 nM-285 nM

Solubility *

In vitro (25°C)	DMSO	85 mg/mL (109.53 mM)
	Water	Insoluble
	Ethanol	85 mg/mL (109.53 mM)
In vivo	5% DMSO+40% PEG 300+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.05 mL	65.27 mL	130.55 mL
0.5 mM	2.61 mL	13.05 mL	26.11 mL
1 mM	1.31 mL	6.53 mL	13.05 mL
5 mM	0.26 mL	1.31 mL	2.61 mL

*The above data is based on the productmolecular weight 766.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.