Apremilast (CC 10004)

Catalog No. A11289

Apremilast (CC 10004)是一种新型的PDE4抑制剂，可抑制人类风湿性滑膜细胞自发产生肿瘤坏死因子-α，并改善实验性关节炎。

Technical details

Catalog Num	A11289
M. Wt	460.5
Formula	C22H24N2O7S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	608141-41-9
Synonyms	CC10004, CC-10004
SMILES	CCOC1=C(C=CC(=C1)[C@@H](CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC

Biological Activity

Apremilast (CC 10004)是一种新型的PDE4抑制剂，可抑制人类风湿性滑膜细胞自发产生肿瘤坏死因子-α，并改善实验性关节炎。

Solubility *

In vitro (25°C)	DMSO	85 mg/mL (184.58 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% CMC+0.25% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.72 mL	108.58 mL	217.16 mL
0.5 mM	4.34 mL	21.72 mL	43.43 mL
1 mM	2.17 mL	10.86 mL	21.72 mL
5 mM	0.43 mL	2.17 mL	4.34 mL

*The above data is based on the productmolecular weight 460.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

Apremilast (CC 10004)

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions