AT7519 HCl

Catalog No. A11313

AT7519是多种细胞周期蛋白依赖性激酶（CDK）的抑制剂，可导致细胞周期停滞，诱导细胞凋亡和抑制肿瘤细胞增殖。

Technical details

Catalog Num	A11313
M. Wt	418.7
Formula	C16H17Cl2N5O2.HCl
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	902135-91-5
Synonyms	AT 7519, AT-7519
SMILES	C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl.Cl

Biological Activity

AT7519是多种细胞周期蛋白依赖性激酶（CDK）的抑制剂，可导致细胞周期停滞，诱导细胞凋亡和抑制肿瘤细胞增殖。

Targets

Target	Value
CDK9/CyclinT	IC50: <10nM
CDK5/p35	IC50: 13nM
CDK2/CyclinA	IC50: 47nM
GSK-3β	IC50: 89nM
CDK4/CyclinD1	IC50: 100nM
CDK6/CyclinD3	IC50: 170nM
CDK1/CyclinB	IC50: 210nM
CDK3/CyclinE	IC50: 360nM
PI3Kβ	IC50: >1μM
PLK3	IC50: >1μM
RET	IC50: >1μM
SGK	IC50: >1μM
TrkB	IC50: >1μM
JAK2	IC50: >1μM
CDK7/CyclinH/MAT1	IC50: 2.4μM
SAPK2A(p38α)	IC50: >10μM
p70S6K	IC50: >10μM
PDGFR	IC50: >10μM
PDK-1	IC50: >10μM
PKBβ	IC50: >10μM
VEGFR1	IC50: >10μM
AuroraA	IC50: >10μM
c-Abl	IC50: >10μM
c-Src	IC50: >10μM
Chk1	IC50: >10μM
EGFR	IC50: >10μM
FGFR3	IC50: >10μM
IR	IC50: >10μM
JNK2	IC50: >10μM
MAPK1	IC50: >10μM
MEK1	IC50: >10μM
Met	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	Warmed: 49 mg/mL (117.03 mM)
	Water	Warmed: 40 mg/mL (95.53 mM)
	Ethanol	Warmed: 26 mg/mL (62.09 mM)
In vivo	Saline	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.88 mL	119.42 mL	238.83 mL
0.5 mM	4.78 mL	23.88 mL	47.77 mL
1 mM	2.39 mL	11.94 mL	23.88 mL
5 mM	0.48 mL	2.39 mL	4.78 mL

*The above data is based on the productmolecular weight 418.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.