Cabozantinib S-malate

Catalog No. A11349

Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.

Product Citations

Paula Sagmeister, .et al. Comparative Response of HCC Cells to TKIs: Modified in vitro Testing and Descriptive Expression Analysis, J Hepatocell Carcinoma, 2022, Jul 9;9:595-607 PMID: 35845819
Aya Hasan Alshammari, .et al. Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition, Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812

Technical details

Catalog Num	A11349
M. Wt	635.59
Formula	C32H30FN3O10
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1140909-48-3
Synonyms	XL184 S-malate; BMS-907351 S-malate
SMILES	O=C([C@H](CC(O)=O)O)O.O=C(NC1=CC=C(C=C1)OC2=CC=NC3=CC(OC)=C(C=C23)OC)C4(CC4)C(NC5=CC=C(C=C5)F)=O

Biological Activity

Solubility *

In vitro (25°C)	DMSO	91 mg/mL (143.17 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.73 mL	78.67 mL	157.33 mL
0.5 mM	3.15 mL	15.73 mL	31.47 mL
1 mM	1.57 mL	7.87 mL	15.73 mL
5 mM	0.31 mL	1.57 mL	3.15 mL

*The above data is based on the productmolecular weight 635.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.