Ixabepilone

Catalog No. A11449

Ixabepilone是epothilone B类似物。

Product Citations

Dong-Sheng Cao, .et al. A Multi-Scale Systems Pharmacology Approach Uncovers the Anti-Cancer Molecular Mechanism of Ixabepilone, Eur J Med Chem, 2020, Aug 1;199:112421 PMID: 32428794
Hoque M, .et al. Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors, Pharmacol Res, 2018, Aug;134:166-178 PMID: 29944980
APRIL L. RISINGER, .et al. Breast Cancer Cell Lines Exhibit Differential Sensitivities to Microtubule-targeting Drugs Independent of Doubling Time, Anticancer Res, 2015, Nov; 35(11): 5845-5850. PMID: 26504006

Technical details

Catalog Num	A11449
M. Wt	506.7
Formula	C27H42N2O5S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	219989-84-1
Synonyms	BMS-24755, Azaepothilone , BMS 247550-1
SMILES	C[C@H]1CCC[C@@]2([C@@H](O2)C[C@H](NC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C

Biological Activity

Ixabepilone是epothilone B类似物。

Targets

microtubule(tubulin stabilising)

Solubility *

In vitro (25°C)	DMSO	95 mg/mL (187.48 mM)
	Water	Insoluble
	Ethanol	95 mg/mL (187.48 mM)
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	6 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.74 mL	98.68 mL	197.36 mL
0.5 mM	3.95 mL	19.74 mL	39.47 mL
1 mM	1.97 mL	9.87 mL	19.74 mL
5 mM	0.39 mL	1.97 mL	3.95 mL

*The above data is based on the productmolecular weight 506.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.