Macitentan

Catalog No. A11492

Macitentan是一种口服活性非肽双重ETA/ETB(内皮素) receptor双重拮抗剂，IC50为0.5 nM/391 nM。用于治疗特发性肺纤维化(IPF)和肺动脉高压(PAH)。

Technical details

Catalog Num	A11492
M. Wt	588.27
Formula	C19H20Br2N6O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	441798-33-0
Synonyms	ACT 064992, ACT-064992, ACT064992
SMILES	CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br

Biological Activity

Macitentan是一种口服活性非肽双重ETA/ETB(内皮素) receptor双重拮抗剂，IC50为0.5 nM/391 nM。用于治疗特发性肺纤维化(IPF)和肺动脉高压(PAH)。

Targets

ET-A	ET-B
0.5 nM	391 nM

Solubility *

In vitro	DMSO	87 mg/mL (147.88 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17 mL	84.99 mL	169.99 mL
0.5 mM	3.4 mL	17 mL	34 mL
1 mM	1.7 mL	8.5 mL	17 mL
5 mM	0.34 mL	1.7 mL	3.4 mL

*The above data is based on the productmolecular weight 588.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.