RG7112

Catalog No. A11523

RG7112是首个临床小分子MDM2抑制剂，HTRF IC50为18 nM，设计用于占据MDM2的p53结合口袋。

Technical details

Catalog Num	A11523
M. Wt	727.78
Formula	C38H48Cl2N4O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	939981-39-2
Synonyms	RG-7112, RG 7112, RO5045337
SMILES	CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C(N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)Cl

Biological Activity

RG7112是首个临床小分子MDM2抑制剂，HTRF IC50为18 nM，设计用于占据MDM2的p53结合口袋。

Solubility *

In vitro (25°C)	DMSO	97 mg/mL (133.55 mM)
	Water	Insoluble
	Ethanol	97 mg/mL (133.55 mM)
In vivo	1% CMC Na	13 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.74 mL	68.7 mL	137.4 mL
0.5 mM	2.75 mL	13.74 mL	27.48 mL
1 mM	1.37 mL	6.87 mL	13.74 mL
5 mM	0.27 mL	1.37 mL	2.75 mL

*The above data is based on the productmolecular weight 727.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

RG7112

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions