SB-408124

Catalog No. A11567

SB-408124是一种选择性的非肽orexin OX1受体拮抗剂(人OX1和OX2受体的Kb值分别为21.7和1405 nM)。体内口服后阻断orexin-A诱导的修饰。

Technical details

Catalog Num	A11567
M. Wt	356.37
Formula	C19H18F2N4O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	288150-92-5
Synonyms	SB408124, SB 408124
SMILES	CC1=NC2=C(C=C(C=C2C(=C1)NC(=O)NC3=CC=C(C=C3)N(C)C)F)F

Biological Activity

SB-408124是一种选择性的非肽orexin OX1受体拮抗剂(人OX1和OX2受体的Kb值分别为21.7和1405 nM)。体内口服后阻断orexin-A诱导的修饰。

Targets

OX1 (membrane)	OX1 (whole cell)
27 nM(Ki)	57 nM(Ki)

Solubility *

In vitro (25°C)	DMSO	35 mg/mL (98.2 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.06 mL	140.3 mL	280.61 mL
0.5 mM	5.61 mL	28.06 mL	56.12 mL
1 mM	2.81 mL	14.03 mL	28.06 mL
5 mM	0.56 mL	2.81 mL	5.61 mL

*The above data is based on the productmolecular weight 356.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.