Torin 1

Catalog No. A11587

Torin1是mTOR的有效抑制剂，IC50为2-10 nM。

Product Citations

Andromachi Lambrianidou, .et al. mTORC2 deploys the mRNA binding protein IGF2BP1 to regulate c-MYC expression and promote cell survival, Cell Signal, 2021, Apr;80:109912 PMID: 33388443
Kowalsky AH, .et al. The GATOR2?CmTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation, J Biol Chem, 2020, Feb 14;295(7):1769-1780 PMID: 31915252
Ashyad Rayhan, .et al. Using genetic buffering relationships identified in fission yeast to reveal susceptibilities in cells lacking hamartin or tuberin function, Biol Open, 2018, Jan 15; 7(1): bio031302 PMID: 29343513
Jin H. Song, .et al. Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase, Mol Cancer Ther, 2018, Dec;17(12):2710-2721 PMID: 30190422

Technical details

Catalog Num	A11587
M. Wt	607.62
Formula	C35H28F3N5O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1222998-36-8
Synonyms	Torin1
SMILES	CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F

Biological Activity

Torin1是mTOR的有效抑制剂，IC50为2-10 nM。

Targets

Target	Value
mTORC1	IC50: 2nM
mTOR	IC50: 4.32nM
DNA-PK	IC50: 6.34nM
mTORC2	IC50: 10nM
p110γ	IC50: 171nM
C2α	IC50: 176nM
p110α/p85α	IC50: 250nM
hVPS34	IC50: 533nM
C2β	IC50: 549nM
p110δ/p85α	IC50: 564nM
PI4Kβ	IC50: 6680nM
PI4Kα	IC50: >10μM

Solubility *

In vitro	DMSO	2 mg/mL (3.29 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.46 mL	82.29 mL	164.58 mL
0.5 mM	3.29 mL	16.46 mL	32.92 mL
1 mM	1.65 mL	8.23 mL	16.46 mL
5 mM	0.33 mL	1.65 mL	3.29 mL

*The above data is based on the productmolecular weight 607.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.